2D and 3D CTC Culture

Cell culture application

Optimizing CTC culture
with 2D and 3D techniques

ScreenCell technology offers researchers an innovative solution for the isolation and 2D and 3D CTC culture, directly from patients’ blood.

By enabling the CTC culture, ScreenCell facilitates the in-depth study of their biological behavior, proliferation and molecular characteristics.

This approach is a major asset for basic research, providing a unique model to explore the mechanisms of tumor progression, cancer heterogeneity and the identification of new therapeutic targets.

comparatif culture de cellules tumorales circulantes

2D CTC culture on MB isolation support

ScreenCell technology plays a key role in the success of this technique by ensuring the viability and proliferative and invasive potential of isolated CTCs. The cells of interest are captured alive, then cultured under optimized conditions to promote their expansion and ex-vivo characterization.

With this method, it is possible to analyze specific subpopulations of CTCs, while preserving their ability to model complex biological phenomena.

ScreenCell kits for
2D and 3D CTC culture

ScreenCell MB kit

MB

Blood sample < 4 hours

Isolated living cells on the isolation support

LCD

Blood sample < 4 hours

Living cells detached
from the suspended isolation support

Little by little, the CTCs are making their nest

Day 7 of CTC culture

ctc culture

Day 23 of CTC culture

day 23 CTC culture

ScreenCell devices have been specifically designed to provide a favorable microenvironment for the isolation and expansion of CTCs, opening unique perspectives to study the mechanisms of metastasis and resistance to anticancer treatments.

In addition, isolated cells can also be detached from their membrane support and suspended, providing additional flexibility for their analysis. This alternative allows the examination of single cells, as well as the exploration of advanced applications such as 3D CTC culture.

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Liquid biopsy for
enhancing patient care
through reliable CTC analysis

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