ScreenCell technology offers researchers an innovative solution for the isolation and 2D and 3D CTC culture, directly from patients’ blood.
By enabling the CTC culture, ScreenCell facilitates the in-depth study of their biological behavior, proliferation and molecular characteristics.
This approach is a major asset for basic research, providing a unique model to explore the mechanisms of tumor progression, cancer heterogeneity and the identification of new therapeutic targets.
2D CTC culture on MB isolation support
ScreenCell technology plays a key role in the success of this technique by ensuring the viability and proliferative and invasive potential of isolated CTCs. The cells of interest are captured alive, then cultured under optimized conditions to promote their expansion and ex-vivo characterization.
With this method, it is possible to analyze specific subpopulations of CTCs, while preserving their ability to model complex biological phenomena.
Échantillon sanguin
< 4 heures
Cellules vivantes détachées
du support d’isolement pour analyse en suspension
Blood sample < 4 hours
Living cells detached
from the suspended isolation support
Day 7 of CTC culture
Day 23 of CTC culture
ScreenCell devices have been specifically designed to provide a favorable microenvironment for the isolation and expansion of CTCs, opening unique perspectives to study the mechanisms of metastasis and resistance to anticancer treatments.
In addition, isolated cells can also be detached from their membrane support and suspended, providing additional flexibility for their analysis. This alternative allows the examination of single cells, as well as the exploration of advanced applications such as 3D CTC culture.
Are you interested in establishing a fundamental or clinical research project focused on circulating tumor cells (CTCs) or liquid biopsy ?
Share your project details with us, and we will be delighted to assist you in bringing it to fruition.
By Amira Mehtar, Janine Wechsler, Christophe Desterke, Julien Giron-Michel, Amira Bouzidi, Aude Burlion, Fawzia Louache, Samira Kahia-Tani , Georges Uzan, and Sina Naserian
