ScreenCell sponsors Molecular Med TRI-CON, February 9-14 2014, San Francisco
Cancer channel – Circulating Tumor Cells (Spotlight on Clinical Validation)
February 11th 12:00 pm Characterization of Circulating Large Cells Isolated by ScreenCell-Filtration in Renal Tumor Patients
Karoline Lackner, M.D., Professor, Pathology, Institute of Pathology, Medical University of Graz
Circulating non-hematologic cells (CNHCs) – putative CTCs/CTMs – isolated from blood by ScreenCell filtration in 40 patients with renal tumors were characterized. We found that CNHC-clusters with malignant or uncertain malignant cytomorphological features were CD45neg/CD31pos. Array-CGH revealed a balanced genome in 83% of cytomorphologically malignant/uncertain malignant CNHC-clusters whereas 17% showed genomic DNA imbalances not found in the primary tumors. Thus the majority of CNHC-clusters may be of endothelial origin.