A New Device for Rapid Isolation by Size and Characterization of Rare Circulating Tumor Cells

ScreenCell.com Published on March 28th, 2011

Abstract. Background: Circulating tumor cells (CTCs) likely derive from clones in the primary tumor, suggesting that they can be used for all biological tests applying to the primary cells. Materials and Methods: The ScreenCell® devices are single-use and low-cost innovative devices that use a filter to isolate and sort tumor cells by size. Results: The ScreenCell® Cyto device is able to isolate rare, fixed, tumor cells, with a high recovery rate. Cells are well preserved morphologically. Immunocytochemistry and FISH assays can be performed directly on the filter. The ScreenCell® CC device allows isolation of live cells able to grow in culture. High quality genetic materials can be obtained directly from tumor cells isolated on the ScreenCell® MB device filter. Conclusion: Due to their reduced size, versatility, and capacity to isolate CTCs within minutes, the ScreenCell® devices may be able to simplify and improve non-invasive access to tumor cells.

Read the full article : http://www.iiar-anticancer.org/openAR/journals/index.php/anticancer/index

 

ISABELLE DESITTER1*, BELLA S. GUERROUAHEN1*, NAOUAL BENALI-FURET1*,

JANINE WECHSLER1, PASI A. JANNE2, YANAN KUANG3, MASAHIKO YANAGITA3,

LILIN WANG3, JILLIAN A. BERKOWITZ3, ROBERT J. DISTEL3 and YVON E. CAYRE1,4

1ScreenCell, 75012 Paris, France;

2Medical Oncology/Solid Tumor Oncology and 3Translational Research Laboratory,

Center For Clinical and Translational Research, Dana-Farber Cancer Institute, Boston MA 02115, U.S.A.; 4Hôpital Robert Debré and Pierre and Marie Curie University, 75019 Paris, France


 


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